Treatment of auricular hematomas by OK-432: How and why it works

Nobuo Ohta, Shigeru Fukase, Yusuke Kusano, Yutaro Saito, Yutaka Tateda, Yusuke Ishida, Ryoukichi Ikeda, Muneharu Yamazaki, Junya Ono, Kenji Izuhara

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Objectives: The aim of this article was to investigate the effectiveness and underlying mechanisms of OK-432 therapy in patients with auricular hematomas. Study Design and Setting: Case series with planned data collection. Subjects and Methods: We tried this therapy in 47 patients with auricular hematoma between April 2008 and August 2018. We aspirated as much of the fluid content of each lesion as possible with a 21-gage needle. We injected OK-432 solution into the lesion with the same needle that we used for aspiration. We performed this treatment at an outpatient basis without hospitalization. Results: Disappearance and marked reduction of the lesion were observed in all patients who had this therapy, and local scarring and deformity of the auricle did not occur in any patients. As adverse effects, local pain at the injection site and fever (37–38.58C) were observed in some cases of the patients who had this therapy. The concentrations of various cytokines in each aspirate before and after OK-432 therapy were investigated. The production of tumor necrosis factor-a, interleukin-6, interleukin-8, interferon gamma, vascular endothelial growth factor, and periostin was significantly elevated in the aspirate fluid after OK-432 therapy. Conclusion: OK-432 therapy is simple, easy, safe, effective, and can be used as a substitute for surgery in the treatment of auricular hematoma.

Original languageEnglish
Pages (from-to)E820-E823
JournalOtology and Neurotology
Issue number8
Publication statusPublished - 2019 Sep 1
Externally publishedYes


  • Auricular hematomas
  • Cytokines
  • OK-432

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology


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