Treatment and prevention of COPD exacerbation

Mutsuo Yamaya, Hiroyasu Yasuda, Motoki Yoshida, Hidekazu Nishimura, Katsutoshi Nakayama

Research output: Contribution to journalReview articlepeer-review


Airway inflammation, mucosal edema, epithelial hyperpermeability, mucus secretion and airway smooth muscle contraction induced by airway bacterial, virus infection and exposure to air pollution may be associated with COPD exacerbation. Severity of COPD exacerbation is estimated by blood gas analysis, serum CRP values and the chest radiograph. Patients with COPD exacerbations are recommended to be treated with additional inhalations of beta-2 agonists and anti -cholinergic agents, systemic administered glucocorticosteroids, oxygen inhalation, and, in cases with purulent sputum, antibiotics. Glucocorticosteroids, beta-2 agonists and anti-cholinergic agents reduce the frequency of COPD exacerbation. We reported the inhibitory effects of glucocorticosteroids on rhinovirus infection, the major cause of common colds, and the inhibitory effects of L-carbocisteine and erythromycin on COPD exacerbations and rhinovirus infection.

Original languageEnglish
Pages (from-to)734-739
Number of pages6
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number4
Publication statusPublished - 2007 Apr

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Treatment and prevention of COPD exacerbation'. Together they form a unique fingerprint.

Cite this