Travoprost with sofZia® preservative system lowered intraocular pressure of Japanese normal tension glaucoma with minimal side effects

Shiro Mizoue, Tadashi Nakano, Nobuo Fuse, Aiko Iwase, Shun Matsumoto, Keiji Yoshikawa, Kiyoshi Yaoeda, Takeshi Hara, Itaru Kimura, Tairo Kimura, Hirotaka Suzumura, Toyoaki Tsumura, Mami Nanno, Shuji Matsukura, Tomihiko Tanino, Koji Nitta, Shigeki Yamabayashi, Reiko Sugimoto, Kazuya Yamagishi, Jun KozakiTakanori Mizoguchi, Mineo Ozaki, Kazuhiko Unoki

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Background: This study aimed to evaluate the effect of travoprost with sofZia® preservative system for lowering the intraocular pressure (IOP) of Japanese normal tension glaucoma (NTG) patients. Methods: In this prospective, multicenter, open-label study, Japanese NTG patients with baseline IOPs <20 mmHg were enrolled after three consecutive time measurements taken at screening and baseline visits. Travoprost with sofZia® was instilled once daily. Lowering effect on IOP, conjunctival hyperemia, superficial punctate keratopathy, and adverse events were examined at week 4, 8, and 12 after drug instillation. Results: One-hundred and three of the 107 enrolled patients (baseline IOP =15.2±2.0 mmHg [mean ± standard deviation]) completed the study. The mean IOP value as well as percent reduction was significantly reduced at each visit after travoprost with sofZia® initiation (P<0.0001). The conjunctival hyperemia score was 1 or less throughout the study, though it increased significantly over time. No significant change was observed in superficial punctate keratopathy. The cumulative incidence of side effects such as eyelash changes, eyelid pigmentation, and deepening of the upper lid was 47.6%, 27.2%, and 16.5%, respectively. Conclusion: Travoprost preserved with sofZia® effectively lowered the IOP of Japanese NTG patients. It was well tolerated with few discontinuations due to adverse events.

Original languageEnglish
Pages (from-to)347-354
Number of pages8
JournalClinical Ophthalmology
Volume8
DOIs
Publication statusPublished - 2014 Feb 3

Keywords

  • Normal Tension Glaucoma (NTG)
  • Prostaglandin analogue
  • Travoprost with sofZia® preservative system

ASJC Scopus subject areas

  • Ophthalmology

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