Transurethral microwave thermotherapy for benign prostatic hyperplasia: Relation between clinical response and prostate histology

Yoichi Arai, Shigeki Fukuzawa, Akito Terai, Osamu Yoshida

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

The effectiveness of transurethral microwave thermotherapy (TUMT) for BPH has been confirmed. To identify the characteristics of the ideal candidate, retrospective analysis and morphometric study of prostatic tissue were performed. Forty-two patients with symptomatic BPH were included in the study; these comprised 10 patients treated for more than 3 months with anti- androgen pre-TUMT (group A) and 32 fresh cases (group B). Subjective and objective responses were evaluated at 2 months post TUMT. In 12 fresh cases who underwent pre-TUMT biopsy of the prostate, the stromal-to-epithelial ratio was determined via quantitative image analysis on a computer-assisted morphometry system. No significant differences in baseline patient characteristics were found between the two groups: age, prostate volume, peak flow rate (PFR), or International Prostate Symptom Score (I-PSS). However, significant differences in treatment outcome were found between the two groups (group A vs. group B, respectively): total energy delivered to the prostate: 96 kJ vs. 125 kJ; I-PSS decrease from baseline: 5.9 vs. 11.6; PFR increase from baseline: 1.1 vs. 4.7 ml/sec. There was a positive correlation between the I-PSS change from baseline and the stromal-to-epithelial ratio of the prostatic tissue (r = 0.4857). The results suggest that microwave interacts poorly with the prostate due to the artificially created 'lack' of glandular tissue. The morphometric study also supports the contention that the histological composition of the prostatic tissue plays an important role in terms of microwave thermal interactions and treatment outcome.

Original languageEnglish
Pages (from-to)84-88
Number of pages5
JournalProstate
Volume28
Issue number2
DOIs
Publication statusPublished - 1996 Feb 1

Keywords

  • benign prostatic hyperplasia
  • prostate histology
  • transurethral microwave thermotherapy

ASJC Scopus subject areas

  • Oncology
  • Urology

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