Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabbit eyes

Hirokazu Sakaguchi, Takashi Fujikado, Xiaoyun Fang, Hiroyuki Kanda, Makoto Osanai, Kazuaki Nakauchi, Yasushi Ikuno, Motohiro Kamei, Tohru Yagi, Shigeru Nishimura, Masahito Ohji, Tetsuya Yagi, Yasuo Tano

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Purpose: Several approaches for placing an electrode device for visual prosthesis have been previously proposed. In this study, we investigated if transretinal stimulation from the suprachoroidal space can elicit an electrical evoked potential (EEP) in albino rabbits. Methods: A flat electrode array (polyimide plate, platinum electrode) was developed and used for this study. After performing a scleral incision at 2-2.5 mm from the limbus and placing an anchoring suture, the array was inserted into the suprachoroidal space in the posterior portion of the eye by direct observation under a microscope. A platinum wire was implanted into the vitreous space as a reference electrode. For electrical stimulation, a biphasic pulse was used. When the electrode was stimulated, the EEP was recorded. Results: When the electrical stimulation from the suprachoroidal space was applied, the EEP could be recorded with an epidural electrode, and the threshold was 66.0 ± 32.1 μA (42.0 μC/Cm2). Histological examination indicated the absence of major damage to the retina and choroid from the insertion and placement of the array and the electrical stimulation. Conclusions: Transretinal electrical stimulation from the suprachoroidal space could elicit EEP, suggesting that this approach may be useful for a retinal prosthesis system.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalJapanese Journal of Ophthalmology
Volume48
Issue number3
DOIs
Publication statusPublished - 2004 May

Keywords

  • Electrical stimulation
  • Electrode
  • Suprachoroid
  • Transretinal stimulation
  • Visual prosthesis

ASJC Scopus subject areas

  • Ophthalmology

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    Sakaguchi, H., Fujikado, T., Fang, X., Kanda, H., Osanai, M., Nakauchi, K., Ikuno, Y., Kamei, M., Yagi, T., Nishimura, S., Ohji, M., Yagi, T., & Tano, Y. (2004). Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabbit eyes. Japanese Journal of Ophthalmology, 48(3), 256-261. https://doi.org/10.1007/s10384-004-0055-1