Transmural, interventricular, apicobasal and anteroposterior action potential duration gradients are all essential to the genesis of the concordant and realistic T wave: A whole-heart model study

Yi Zheng, Daming Wei, Xin Zhu, Wenxi Chen, Koji Fukuda, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Background It has been reported that ventricular repolarization dispersion resulting from transmural, apicobasal and interventricular action potential duration (APD) gradients makes the T wave concordant with the QRS complex. Method and results A whole-heart model integrating transmural, apicobasal, interventricular and anteroposterior APD gradients was used, and the corresponding electrocardiograms were simulated to study the influence of these APD gradients on the T-wave amplitudes. The simulation results showed that changing a single APD gradient (e.g., interventricular APD gradient alone) only made substantial changes to the T-wave amplitudes in a limited number of leads and was not able to generate T waves with amplitudes comparable with clinical findings in all leads. A combination of transmural, apicobasal and interventricular APD gradients could simulate T waves with amplitudes similar to clinical values in the limb leads only. Adding the anteroposterior APD gradient into the model greatly improved the consistency between the simulated T-wave amplitudes and the clinical values. Conclusion The simulation results support that the transmural, apicobasal, interventricular and the anteroposterior APD gradient are all essential to the genesis of the clinical T wave.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalJournal of Electrocardiology
Volume49
Issue number4
DOIs
Publication statusPublished - 2016 Jul 1

Keywords

  • Action potential duration gradient
  • Computer simulation
  • Electrocardiogram
  • T wave
  • Whole-heart model

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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