Transmission of respiratory syncytial virus among children under 5 years in households of rural communities, the philippines

Hirono Otomaru, Taro Kamigaki, Raita Tamaki, Michiko Okamoto, Portia Parian Alday, Alvin Gue Tan, Joanna Ina Manalo, Edelwisa Segubre-Mercado, Marianette Tawat Inobaya, Veronica Tallo, Socorro Lupisan, Hitoshi Oshitani

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background. To develop a more effective vaccination strategy for reducing the impact of respiratory syncytial virus (RSV) infection, especially in young infants (<6 months old), it is necessary to understand the transmission dynamics of RSV. Methods. We conducted a community-based prospective cohort study from 2014 to 2016 in Biliran Province, the Philippines, on children <5 years old. We collected nasopharyngeal swabs from symptomatic children with acute respiratory infection (ARI) during household visits and at health facilities. In households (n = 181) with RSV-positive ARI cases (RSV-ARI), we also identified ARI episodes among other children <5 years old in the same household. In addition, we determined the serial interval to estimate the basic reproduction number (R0), the average number of secondary cases generated by a single primary case. Results. In the 181 households analyzed, we found 212 RSV-ARI in 152 households with a single case and 29 households with multiple cases, which included 29 1st RSV-ARI and 31 2nd RSV-ARI. We also found possible index cases among children <5 years old in the same household for 29.0% (18 of 62) of young infants with RSV-ARI. The estimated mean serial interval was 3.2 days, and R0 was estimated to be 0.92-1.33 for RSV-A and 1.04-1.76 for RSV-B, which varied between different times (2014 and 2015) and places. Conclusions. Young infants are likely to acquire RSV infection from older children in the same household. Therefore, vaccination targeting older children might protect infants from RSV infection.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Volume6
Issue number3
DOIs
Publication statusPublished - 2019 Mar

Keywords

  • Basic reproduction number
  • Household transmission
  • Respiratory syncytial virus
  • Serial interval
  • Transmission dynamics

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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