Translocation (3;16)(q27;p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement

Ryo Ichinohasama, Ikuo Miura, Tomoaki Shishido, Keisuke Matsumoto, Yoshinaka Shimizu, Tohru Miki, John F. DeCoteau, Marshall E. Kadin, Kiyoshi Ooya

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A patient with B-cell lineage diffuse large-cell lymphoma carrying the t(3;16)(q27;p11) and BCL-6 rearrangement is described. Cytogenetic studies showed 46,XY,t(3;16)(q27;p11.2)[11]/46,idem,add(18)(q21)[7]/46,XY[2]. The chromosomal translocation involving the 3q27 locus was associated with the BCL-6 gene rearrangement identified by Southern blot analysis. This case involved systemic lymph nodes, as large as 3 cm in diameter, bilaterally in neck, axilla, and inguinal regions. The patient obtained complete remission with chemotherapy.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume103
Issue number2
DOIs
Publication statusPublished - 1998 Jun 1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint

Dive into the research topics of 'Translocation (3;16)(q27;p11) in a patient with diffuse large B-cell lymphoma associated with the BCL-6 gene rearrangement'. Together they form a unique fingerprint.

Cite this