TY - JOUR
T1 - Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons
AU - Wakamatsu, Yoshio
AU - Watanabe, Yuko
AU - Shimono, Akihiko
AU - Kondoh, Hisato
N1 - Funding Information:
We thank Mr. N. Nozaki for assistance in peptide synthesis, the Radioisotope Research Center of Nagoya University for experimental facilities, and Drs. H. Fujisawa and S. Sawai for discussions. This work was supported by grants from the Ministries of Education, Science and Culture and of Health and Welfare, Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate fact.
PY - 1993/1
Y1 - 1993/1
N2 - N-myc is a developmentally regulated proto-oncogene encoding a putative sequence-specific DNA-binding protein. Previous studies on tissue distribution of N-myc transcripts indicated that one of the major sites of N-myc expression is the CNS and neural crest derivatives in developing embryos. We investigated N-Myc protein expression in embryonic neural tissues and found that the protein was usually localized in the nucleus, but accumulated in the cytoplasm upon differentiation of specific classes of neurons, e.g., retinal ganglion cells, neurons of spinal ganglia, and Purkinje cells of the cerebellum. The change of localization of N-Myc from the nucleus to the cytoplasm indicates a novel feature of regulation of myc family proteins and suggests functions of N-myc in the cytoplasm of maturing neurons.
AB - N-myc is a developmentally regulated proto-oncogene encoding a putative sequence-specific DNA-binding protein. Previous studies on tissue distribution of N-myc transcripts indicated that one of the major sites of N-myc expression is the CNS and neural crest derivatives in developing embryos. We investigated N-Myc protein expression in embryonic neural tissues and found that the protein was usually localized in the nucleus, but accumulated in the cytoplasm upon differentiation of specific classes of neurons, e.g., retinal ganglion cells, neurons of spinal ganglia, and Purkinje cells of the cerebellum. The change of localization of N-Myc from the nucleus to the cytoplasm indicates a novel feature of regulation of myc family proteins and suggests functions of N-myc in the cytoplasm of maturing neurons.
UR - http://www.scopus.com/inward/record.url?scp=0027403256&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027403256&partnerID=8YFLogxK
U2 - 10.1016/0896-6273(93)90236-K
DO - 10.1016/0896-6273(93)90236-K
M3 - Article
C2 - 8427698
AN - SCOPUS:0027403256
SN - 0896-6273
VL - 10
SP - 1
EP - 9
JO - Neuron
JF - Neuron
IS - 1
ER -