Abstract
The transition metal-catalyzed formal [3 + 2] cycloaddition of methylenecyclopropanes with unsaturated compounds X=Y, such as alkenes, aldehydes, and imines, gives five-membered carbocycles or heterocycles. The Heck-type reaction of R-Pd-X with the exomethylene part of methylenecyclopropanes gives the corresponding cyclopropylcarbinylpalladium complexes which undergo further transformations through typical palladium reactions such as β-hydride elimination or reductive elimination of Pd(0). Hydrostannation, hydrosilylation, hydrocarbonation, hydroamination, and hydroalkoxylation of methylenecyclopropanes proceed through the addition of the metal hydrides (H-M) and pronucleophiles (H-Nu) to the olefinic part, and the resulting intermediates are converted to the allylic products in which the homologation by three carbon atoms takes place from M and Nu, respectively. Bismetallation produces 1,3-bimetallic derivatives through metallacyclobutane intermediates.
Original language | English |
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Pages (from-to) | 111-129 |
Number of pages | 19 |
Journal | Advanced Synthesis and Catalysis |
Volume | 344 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2002 Apr |
Externally published | Yes |
Keywords
- Catalytic reaction
- Hydroamination
- Hydrocarbonation
- Methylenecyclopropane
- Transition metals (late)
ASJC Scopus subject areas
- Catalysis
- Organic Chemistry