Transit characteristics of a neutrophil passing through a circular constriction in a cylindrical capillary vessel (Effect of mechanical properties of the cell and constriction geometry)

Atsushi Shirai, Ryo Fujita, Toshiyuki Hayase

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

The former analysis of neutrophil's transit through pulmonary capillary network used the result of a micropipette aspiration experiment to model the transit in single capillary segment despite blunt tip geometry of the pipette is largely different from the real capillary segment. In the previous work, we have numerically investigated the transit of passive and fMLP-stimulated neutrophils through an arc-shaped constriction, establishing the analytical expression for the transit time. This paper intends to give a simplified model for the transit of a neutrophil through a capillary segment based on the numerical analysis and the stress-strain relationship of a Maxwell material. It is shown that the transit time is in proportion to the viscosity of the cell and in inverse proportion to the square root of the curvature radius of the constriction. The definition of the driving pressure of the cell into a micropipette is also applicable to that into the constriction.

Original languageEnglish
Pages (from-to)974-980
Number of pages7
JournalJSME International Journal, Series C: Mechanical Systems, Machine Elements and Manufacturing
Volume45
Issue number4
DOIs
Publication statusPublished - 2002 Dec

Keywords

  • Bio-fluid mechanics
  • Finite element method
  • Fluid-structure interaction
  • Neutrophil
  • Pipe flow
  • Visco elasticity

ASJC Scopus subject areas

  • Mechanical Engineering
  • Industrial and Manufacturing Engineering

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