Transient relief of asthma symptoms during jaundice: A possible beneficial role of bilirubin

Takashi Ohrui, Hiroyasu Yasuda, Mutsuo Yamaya, Toshifumi Matsui, Hidetada Sasaki

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Bilirubin arises from enzymatic reduction by biliverdin reductase of biliverdin, a product of heme oxygenase activity. Recent literature describes that bilirubin is a major physiologic antioxidant that can protect cells from chemical oxidants such as hydrogen peroxide. Recently, it has been reported that oxidative stress may play a crucial role in the pathogenesis of asthma. We report a case of complete resolution of persistent difficult-to-control asthma in accordance with increased levels of serum bilirubin due to acute hepatitis B. The present case suggests that anti-oxidative agents might be effective for the treatment of asthma.

Original languageEnglish
Pages (from-to)193-196
Number of pages4
JournalTohoku Journal of Experimental Medicine
Volume199
Issue number3
DOIs
Publication statusPublished - 2003 Mar 1

Keywords

  • Antioxidant activity
  • Hyperbilirubinemia
  • Intractable asthma
  • Oxidative stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Transient relief of asthma symptoms during jaundice: A possible beneficial role of bilirubin'. Together they form a unique fingerprint.

Cite this