The transient global ischemia model is used to analyze selective neuronal death in vulnerable regions including the CA1 subregion of the hippocampus and in certain cortical neurons. In this mouse global ischemia model, bilateral common carotid arteries are reversibly occluded, and the individual anatomical backgrounds are normalized by evaluating the patency of the posterior communicating artery. Using this evaluation, this model might be used for mouse strains with various genetic backgrounds.
- Blood flow
- Delayed neuronal death
- Global cerebral ischemia model
- Ischemic brain injury
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)