Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases

Noriyuki Obara, Yoshiyuki Ueno, Koji Fukushima, Yu Nakagome, Eiji Kakazu, Osamu Kimura, Yuta Wakui, Osamu Kido, Masashi Ninomiya, Takayuki Kogure, Jun Inoue, Yasuteru Kondo, Masaaki Shiina, Takao Iwasaki, Takeshi Yamamoto, Tooru Shimosegawa

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Background: Many studies have reported the efficiency of transient elastography, a noninvasive, reproducible, and reliable method for predicting liver fibrosis, in patients with chronic hepatitis C (CHC) and B (CHB), but there are few reports about nonviral chronic liver disease (CLD) such as primary biliary cirrhosis (PBC), nonalcoholic steatohepatitis (NAFLD), and autoimmune hepatitis (AIH). We therefore compared the efficiency of transient elastography between CHC and nonviral CLD. Methods: We assessed the accuracy of liver stiffness measurement (LSM) using Fibroscan, and compared these values with those of hyaluronic acid, type 4 collagen, platelet count, prothrombin index, and AST/ platelet ratio index (APRI) as indices for the diagnosis of liver fibrosis in 114 patients with a variety of chronic liver diseases: CHC (n = 51), CHB (n = 11), NAFLD (n = 17), PBC (n = 20), and AIH (n = 15). The histology was assessed according to the METAVIR score by two pathologists. Results: The number of fibrosis stage (F0/1/2/3/4) with CHC was 9/15/12/ 6/10, and that with nonviral CLD was 10/21/11/4/6, respectively. The ability, assessed by area under receiver operating characteristic (AUROC) curve, to predict liver fibrosis F ≤ 2 for LSM, HA, type 4 collagen, platelet count, prothrombin index, and APRI, was 0.92, 0.81, 0.87, 0.85, 0.85, and 0.92 in CHC patients, respectively; and 0.88, 0.72, 0.81, 0.67, 0.81, and 0.77 in nonviral CLD patients, respectively. Conclusions: In patients with nonviral CLD, LSM was most helpful in predicting significant fibrosis (F ≤ 2). Transient elastography is a reliable method for predicting significant liver fibrosis, not only in CHC patients but also in nonviral CLD patients.

Original languageEnglish
Pages (from-to)720-728
Number of pages9
JournalJournal of gastroenterology
Volume43
Issue number9
DOIs
Publication statusPublished - 2008

Keywords

  • Chronic liver disease
  • Fibrosis
  • NAFLD
  • Transient elastography

ASJC Scopus subject areas

  • Gastroenterology

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