Transfusion-associated graft-versus-host disease in immunocompetent patient: Early diagnosis and therapy

Masahiro Sakurai, Yoshimasa Moizumi, Shigeharu Uchida, Yoshimichi Imai, Koichi Tabayashi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report a case of transfusion-associated graff-versus-host disease in a previously healthy, 68-year-old Japanese man following an emergency surgery for an acute aortic dissection. We confirmed the chimerism of lymphocytes and the effect of drug therapy using DNA polymorphism analysis. This method is a sensitive, convenient, and rapid method that it is also useful for the evaluation of therapy. And the combination therapy with methylprednisolone, cyclosporine, and 15-deoxyspergualin may be effective in treating transfusion-associated GVHD.

Original languageEnglish
Pages (from-to)84-86
Number of pages3
JournalAmerican Journal of Hematology
Volume58
Issue number1
DOIs
Publication statusPublished - 1998 May

Keywords

  • 15-deoxyspergualin
  • Polymorphism analysis of microsatellite DNA
  • TA-GVHD

ASJC Scopus subject areas

  • Hematology

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