Transfer of cholesterol and sitosterol from rat intestinal brush border membranes to phospholipid liposomes: Effects of SCP2

Ikuo Ikeda, George V. Vahouny, Linda L. Gallo, Michihiro Sugano, Terence J. Scallen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Regarding the transport of absorbed sterols to endoplasmic reticulum in intestinal mucosal cells, transfer of cholesterol and sitosterol from rat intestinal brush border membranes to phospholipid liposomes was investigated. Transfer of sitosterol from brush border membranes to liposomes was significantly slower than that of cholesterol. Sitosterol transfer increased dose-dependently with the addition of sterol carrier protein2 (SCP2), but only a transient increase was observed with cholesterol. The results suggest that a slower rate of transfer of sitosterol than cholesterol from brush border membranes to the intracellular site of use may be one mechanism by which sitosterol transport into lymph is delayed, as observed previously in the rat intestine. SCP2 may not essentially participate in the transfer of absorbed cholesterol.

Original languageEnglish
Pages (from-to)2649-2653
Number of pages5
JournalAgricultural and Biological Chemistry
Volume54
Issue number10
DOIs
Publication statusPublished - 1990 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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