Transfer of carmofur (HCFU) to the serum, bile, pancreatic juice and pancreatic tumor tissue in the cases of peri-pancreatic head cancer

Satoshi Akaishi, M. Kobari, T. Yusa, H. Yamanami, Toru Furukawa, S. Matsuno

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2 Citations (Scopus)

Abstract

The concentrations of carmofur, 1-hexyl-carbamoyl-5-fluorouracil (HCFU), in the serum, bile, pancreatic juice and pancreatic tumor tissue were studied in 18 cases of peri-pancreatic head cancer with drainages of the pancreatic and biliary ducts after pancreatico-duodenectomy. As a result, high concentrations of HCFU and 5-FU were detected in the serum, bile and pancreatic juice after a per-oral administration of HCFU, 200 mg: HCFU was high in the order of serum > bile and pancreatic juice, and 5-FU in the order of bile, serum and pancreatic juice. Two hours after administration, 5-FU concentration in the bile and serum attained to the maximum levels of 0.45 and 0.19 μg/ml, respectively, which demonstrated a lasting transfer of 5-FU to the bile at high concentration. HCFU and 5-FU levels in the tumor tissue were 0.079 and 0.024 μg/g, respectively. In conclusion, antitumor effect against the malignant tumors of the pancreatobiliary system can be expected by peroral administration of carmofur.

Original languageEnglish
Pages (from-to)659-664
Number of pages6
JournalJapanese Journal of Cancer and Chemotherapy
Volume22
Issue number5
Publication statusPublished - 1995 Jan 1

Keywords

  • bile
  • carmofur (HCFU)
  • pancreatic tissue
  • pancreatico-duodenectomy

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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