Transesophageal endoscopic ultrasonography guided-fine needle aspiration for the diagnosis of sarcoidosis

Kazue Saito, Yoshinori Tanino, Yayoi Inokoshi, Suguru Sato, Kengo Oshima, Taeko Ishii, Naoko Nakagawa, Atsuro Fukuhar, Kenya Kanazawa, Junpei Saito, Takashi Ishida, Takuto Hikichi, Atsushi Irisawa, Hiromasa Ohira, Mitsuru Munakata

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Sarcoidosis is a multi-organ disorder of unknown etiology characterized by noncaseating epithelioid cell granulomas. The specimen for histopathological diagnosis is usually obtained by transbronchial lung biopsy (TBLB), but the diagnostic accuracy rate of TBLB is not satisfactory, especially for stage I patients. Since hilar and mediastinal lymphadenopathy is a common finding in patients with sarcoidosis, an approach to lymph nodes is expected to have a good diagnosis yield. We present 3 sarcoidosis patients in whom specimens obtained by TBLB, transbronchial needle aspiration (TBNA) and transesophageal endoscopic ultrasonography guided-fine needle aspiration (EUS-FNA). The histopathological appearance of specimens obtained by EUS-FNA for swollen mediastinal lymph nodes showed noncaseating epithelioid granulomas which are characteristic of sarcoidosis in all 3 patients. On the other hand, no specific findings were recognized in the specimens obtained by TBLB and TBNA in 2 out of 3 patients. These results suggest that EUS-FNA is useful to obtain diagnostic specimens in cases of sarcoidosis.

Original languageEnglish
Pages (from-to)996-1001
Number of pages6
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume47
Issue number11
Publication statusPublished - 2009 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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