The human genome carries several endogenous retroviral sequences. One of them that we named 'HERV-A', carries almost the complete sequence of the long terminal repeat (LTR), and is located in the 5′ region of the amylase genes (M.Emi, A.Horii, N.Tomita, T.Nishide, M.Ogawa, T.Mori and K.Matsubara, Gene 62: 229-235, 1988). Using this sequence as a probe, we found a 1.4 kb LTR transcript(s) in a lung cancer cell line. No corresponding transcript was observed in control cells. Two partial, but different cDNA clones were obtained, and each one was found to be a transcript starting within human sequences at 5′ upstream from the LTR and ending within the LTR sequence.
|Number of pages||10|
|Journal||Biochemical and biophysical research communications|
|Publication status||Published - 1990 Jan 15|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology