Transcription of human endogenous retroviral long terminal repeat (LTR) sequence in a lung cancer cell line

Naohiro Tomita, Akira Horii, Sadayuki Doi, Hideoki Yokouchi, Michio Ogawa, Takesada Mori, Kenichi Matsubara

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The human genome carries several endogenous retroviral sequences. One of them that we named 'HERV-A', carries almost the complete sequence of the long terminal repeat (LTR), and is located in the 5′ region of the amylase genes (M.Emi, A.Horii, N.Tomita, T.Nishide, M.Ogawa, T.Mori and K.Matsubara, Gene 62: 229-235, 1988). Using this sequence as a probe, we found a 1.4 kb LTR transcript(s) in a lung cancer cell line. No corresponding transcript was observed in control cells. Two partial, but different cDNA clones were obtained, and each one was found to be a transcript starting within human sequences at 5′ upstream from the LTR and ending within the LTR sequence.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalBiochemical and biophysical research communications
Volume166
Issue number1
DOIs
Publication statusPublished - 1990 Jan 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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