Transcranial surgery for craniopharyngiomas

Reizo Shirane, Toshiaki Hayashi, Teiji Tominaga

Research output: Contribution to journalArticlepeer-review


Objective : The current treatment of craniopharyngiomas is evolving into a multimodal approach in which the aim is disease control and improved preservation of quality of life (QOL). In this the paper, the transcranial removal of craniopharyngiomas is discussed. Method : Fifty-two patients who were surgically treated for craniopharyngiomas extending outside the sellar-suprasellar region were evaluated. All the patients were operated on mainly by the fronto-basal interhemispheric approach. Results : Multiple surgeries were performed in 15 cases. A total of 10 patients were treated with GKS after surgical removal. In the immediate postoperative period, major complications, including impairment of the perforating arteries were observed in three cases. They exhibited hyperphagia and obesity due to infarction of the hypothalamic nuclei. Conclusion : In our experience, the cost of aggressive resection is hypothalamic dysfunction and a poor QOL. A good QOL may be achieved by careful total or near total resection followed by reoperation or GKS. The fronto-basal interhemispheric approach is a valid choice for the removal of craniopharyngiomas extending outside the sellar-suprasellar region. Using this approach, tumors can be removed without significant sequelae related to surgical technique due to easy preservation of the pituitary stalk, hypothalamic structures, and perforators. This approach offers a safe and minimally invasive means of treating craniopharyngiomas.

Original languageEnglish
Pages (from-to)448-457
Number of pages10
JournalJapanese Journal of Neurosurgery
Issue number6
Publication statusPublished - 2007 Jun


  • Complication
  • Craniopharyngioma
  • Hypothalamus
  • Prognosis
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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