TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors

Shuhei Kobayashi, Yuka Shiota, Takeshi Kawabe, Hai The Phung, Takashi Maruyama, Yuji Owada, Takanori So, Naoto Ishii

Research output: Contribution to journalArticlepeer-review

Abstract

The conventional dendritic cells (cDCs) and plasmacytoid DCs (pDCs) originate from the same common dendritic cell precursor cells in the bone marrow. The pDCs produce large amounts of type 1 interferon in response to foreign nucleic acid and crucially contribute to host defense against viral infection. Tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) is a pivotal component of various TNF receptor signaling pathways in the immune system. Although the functions of TRAF5 in T and B lymphocytes have been well studied, its roles in pDCs remains to be fully elucidated. In this study, we show that the expression of TRAF5 supports the generation of pDCs in the bone marrow and also critically contributes to the homeostasis of the pDC subset in the periphery in a cell-intrinsic manner. Furthermore, we provide evidence that TRAF5 promotes the commitment of DC precursor cells toward pDC versus cDC subsets, which is regulated by the balance of transcription factors TCF4 and ID2. Together our findings reveal that TRAF5 acts as a positive regulator of pDC differentiation from bone marrow progenitors.

Original languageEnglish
Pages (from-to)353-359
Number of pages7
JournalBiochemical and biophysical research communications
Volume521
Issue number2
DOIs
Publication statusPublished - 2020 Jan 8
Externally publishedYes

Keywords

  • Cell commitment
  • Plasmacytoid DC
  • TRAF5

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors'. Together they form a unique fingerprint.

Cite this