Tracheobronchial mucociliary clearance and alveolar epithelial permeability measured by PET with18FDG powder

Jun Hatazawa, Masaru Yanai, Masatoshi Itoh, Tatsuo Ido, Fumiyoshi Ojima, Toshihiro Takahashi, T. Aikawa, Hidetada Sasaki, Tamotsu Takishima, Shoichi Watanuki, Shinya Seo, Kenji Abiko, Masafumi Amano

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Tracheobronchial mucociliary clearance and alveolar permeability were measured with positron emission tomography using a water-soluble dry aerosol, sodium-N-acetyl-neuraminate tagged with 2-deoxy-2-[18F]fluoro-D- glucose (18FDG powder). Five normal volunteers inhaled 1.5-2.0 mCi of FDG powder by a single deep breath. The distribution of radioactivity, measured by scanning during a period of 120 min, showed that the 18FDG powder deposition progressed from the central airways to the peripheral alveolar areas. In the tracheobronchial system the radioactivity decreased to 24% of the initial deposition at 60 min. In the peripheral alveolar area, where absorption into blood or lymphatic flow crossing the epithelial layer represents a unique mechanism of clearance for water-soluble 18FDG powder, alveolar radioactivity decreased slowly to~70% of the initial deposition at 60 min after inhalation. Positron emission tomography using18FDG powder provides a regional evaluation of both mucociliary transport in the tracheobronchial system and epithelial permeability in the alveolar area.

Original languageEnglish
Pages (from-to)175-181
Number of pages7
JournalJournal of Computer Assisted Tomography
Volume14
Issue number2
DOIs
Publication statusPublished - 1990 Mar

Keywords

  • Contrast media, Inhalation agents
  • Emission Computed tomography
  • Lungs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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