Abstract
We report here a solid-phase synthesis of a library of mappicine ketone, a leading antiviral compound with activity against herpes viruses and human cytomegalovirus. The synthesis is based on multiple chemoselective palladium-catalyzed reactions involving a regioselective intramolecular Heck reaction at C-2, substitution of Cl at C-7 by Suzuki-Miyaura cross-coupling reaction and Buchwald-Hartwig amination, and reductive cleavage of the benzenesulfonate linker at C-1O.
Original language | English |
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Pages (from-to) | 2005-2010 |
Number of pages | 6 |
Journal | Synlett |
Issue number | 13 |
DOIs | |
Publication status | Published - 2008 Aug 1 |
Keywords
- Benzenesulfonate linker
- Chemoselective
- Mappicine ketone
- Palladium
- Traceless solid-phase synthesis
ASJC Scopus subject areas
- Organic Chemistry