Toxic effects of selenodiglutathione on pregnant mice

Junzo Yonemoto, Tetsuro Hongo, Tsuguyoshi Suzuki, Akira Naganuma, Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 μmol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalToxicology Letters
Volume21
Issue number1
DOIs
Publication statusPublished - 1984 Apr

Keywords

  • Selenite
  • fetotoxicity
  • maternal death
  • pregnant mice
  • selenodiglutathione
  • stillbirth

ASJC Scopus subject areas

  • Toxicology

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