Towards magnetic suspension assay technology

T. J. Hayward, J. Llandro, K. P. Kopper, T. Trypiniotis, T. Mitrelias, J. A.C. Bland, C. H.W. Barnes

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

In this study micromagnetic simulations are used to evaluate two novel approaches of magnetically tagging biomolecules in high-throughput biological assays. Comparisons are made between a simple magnetic moment-based tagging system, where the total magnetic moment of each microscopic tag encodes the identity of an attached biomolecule, and a multibit tagging system, where each tag is comprised of multiple magnetic binary bits. We show that although detection of the tags using magnetoresistive sensors is feasible in both cases, the multibit technology offers over a thousand times more distinct tags than the simple moment encoded approach. The advantages of using multibit magnetic tags to label biomolecules, rather than existing optical tagging techniques, are also discussed.

Original languageEnglish
Title of host publicationBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes
Pages111-124
Number of pages14
DOIs
Publication statusPublished - 2008
Externally publishedYes
EventBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes - Sant Feliu de Guixols, Spain
Duration: 2007 Sep 222007 Sep 27

Publication series

NameAIP Conference Proceedings
Volume1025
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

OtherBiomagnetism and Magnetic Biosystems Based on Molecular Recognition Processes
CountrySpain
CitySant Feliu de Guixols
Period07/9/2207/9/27

Keywords

  • Assay technology
  • Biochips magnetic bead
  • Biosensors
  • Magnetic labels
  • Magnetoresistive sensors

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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