Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: Convergent synthesis of the C15-C36 Segment

Tomoyuki Saito; Haruhiko Fuwa; Makoto Sasaki

doi:10.1021/ol902217q

Toward the total synthesis of goniodomin A, an actin-targeting marine polyether macrolide: Convergent synthesis of the C15-C36 Segment

Tomoyuki Saito, Haruhiko Fuwa, Makoto Sasaki

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

Stereoselective convergent synthesis of the C15-C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind-Srogl cross-coupling as the fragment assembly process.

Original language	English
Pages (from-to)	5274-5277
Number of pages	4
Journal	Organic letters
Volume	11
Issue number	22
DOIs	https://doi.org/10.1021/ol902217q
Publication status	Published - 2009 Dec 3

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol902217q

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abstract = "Stereoselective convergent synthesis of the C15-C36 segment of goniodomin A, an actin-targeting marine polyether macrolide natural product, has been achieved. The present synthesis features palladium(0)-catalyzed, copper(I)-mediated Liebeskind-Srogl cross-coupling as the fragment assembly process.",

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