Toward the Total Synthesis of Amphidinolide N: Synthesis of the C8-C29 Fragment

Yuki Kawashima, Atsushi Toyoshima, Haruhiko Fuwa, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    A synthesis of the C8-C29 fragment of amphidinolide N, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been achieved. The key features of the synthesis involve a convergent union of the C9-C15 and C16-C29 fragments by Steglich esterification and the construction of a pyran unit through a Tebbe methylenation/ring-closing metathesis sequence.

    Original languageEnglish
    Pages (from-to)2232-2235
    Number of pages4
    JournalOrganic letters
    Volume18
    Issue number9
    DOIs
    Publication statusPublished - 2016 May 6

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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