Abstract
A synthesis of the C8-C29 fragment of amphidinolide N, a potent cytotoxic macrolide isolated from the marine dinoflagellate Amphidinium sp., has been achieved. The key features of the synthesis involve a convergent union of the C9-C15 and C16-C29 fragments by Steglich esterification and the construction of a pyran unit through a Tebbe methylenation/ring-closing metathesis sequence.
Original language | English |
---|---|
Pages (from-to) | 2232-2235 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 18 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2016 May 6 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry