Toward identification of susceptibility genes for sporadic Parkinson's disease

Tatsushi Toda, Yoshio Momose, Miho Murata, Gen Tamiya, Mitsutoshi Yamamoto, Nobutaka Hattori, Hidetoshi Inoko

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

To identify susceptibility genes for Parkinson's disease (PD) and to establish tailor-made medicine for PD, we studied 20 single nucleotide polymorphisms (SNPs) in 18 candidate genes for association with PD. We found that homozygosity for the V66M polymorphism of the BDNF gene occurs more frequently in PD patients than in unaffected controls and confirmed an association with the S18Y polymorphism of the UCHL1 gene. We further started microsatellite marker-based genome-wide association studies by using the pooled DNA method. We have finished checking approximately 6800 markers and found some significant associations (p = 3.9 × 10-6) on chromosome 1 where other studies showed a linkage. Genes in linkage disequilibrium with these markers may be associated with pathogenesis of PD.

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalJournal of Neurology, Supplement
Volume250
Issue number3
Publication statusPublished - 2003 Oct 1
Externally publishedYes

Keywords

  • Association
  • Microsatellite
  • Parkinson's disease
  • SNP
  • Susceptibility gene

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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  • Cite this

    Toda, T., Momose, Y., Murata, M., Tamiya, G., Yamamoto, M., Hattori, N., & Inoko, H. (2003). Toward identification of susceptibility genes for sporadic Parkinson's disease. Journal of Neurology, Supplement, 250(3), 40-43.