Toward a total synthesis of amphidinolide N: convergent synthesis of the C1–C13 segment

Atsushi Toyoshima, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    5 Citations (Scopus)

    Abstract

    A convergent synthesis of the C1–C13 segment of amphidinolide N, a potent cytotoxic marine macrolide isolated from the dinoflagellate Amphidinium sp., was achieved. The key features of the synthesis involve vinylogous Mukaiyama and Evans aldol reactions to form the C1–C7 and C8–C13 fragments, and convergent union of the two fragments by means of an aldol reaction to construct the C1–C13 segment.

    Original languageEnglish
    Pages (from-to)3532-3534
    Number of pages3
    JournalTetrahedron Letters
    Volume57
    Issue number31
    DOIs
    Publication statusPublished - 2016 Jan 1

    Keywords

    • Aldol reaction
    • Amphidinolide N
    • Convergent synthesis
    • Cytotoxic macrolide

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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