Total vascular resistance and blood flow frequency during left ventricular assistance using a vibrating flow pump

Shinichi Kobayashi, N. Owada, T. Yambe, S. Nitta, T. Fukuju, T. Hongoh, H. Hashimoto

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A vibrating flow pump (VFP) can generate high frequency oscillated blood flow within 10~30 Hz by the oscillation of its central tube. A totally implantable artificial heart using a VFP is being developed as a unique type of blood pump. In this study, left ventricular (LV) assist circulation was performed using a VFP. The total vascular resistance and driving frequency of the VFP were estimated from their relationship. The effect of oscillation on the vascular system was studied by the frequency analysis method and vascular impedance. Adult goats were anesthetized by halothane using an inhaler and a left fourth thoracotomy was performed. The inflow cannula was inserted into the left ventricle, and the outflow cannula was sutured to the descending aorta. The VFP and a centrifugal pump were set in parallel for alternation and comparison. The driving frequency of the VFP was changed and included 15, 20, 25, and 30 Hz. The hemodynamic parameters were continuously recorded during experiments by a digital audio tape (DAT) data recorder. The internal pressure of the left ventricular cavity and aortic pressure were monitored by the pressure manometers continuously. One hundred percent LV assistance was judged by the separation of LV and aortic pressure. The total vascular resistance was decreased by the start of operation of each pump. The decrease during flow using the VFP was not as large as that using a centrifugal pump (CP). The arterial input impedance during oscillated blood flow by the VFP showed a slow curve appearance. It was similar to the frequency characteristics curve of natural heart beats within the lower frequencies. The study of arterial impedance may be important for the estimation of the reflection of the pulsatile wave from the arterial branch, among other things.

Original languageEnglish
Pages (from-to)732-735
Number of pages4
JournalArtificial Organs
Volume23
Issue number8
DOIs
Publication statusPublished - 1999 Aug 23

Keywords

  • Arterial impedance
  • Arterial resonance
  • Oscillated blood flow
  • Total vascular resistance
  • Vibrating flow pump

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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