Total synthesis of (±)-trachyspic acid and determination of the relative configuration

Kanako Hirai, Hidenori Ooi, Tomoyuki Esumi, Yoshiharu Iwabuchi, Susumi Hatakeyama

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


The first total synthesis of (±)-trachyspic acid, a tumor cell heparanase inhibitor, was accomplished based on Cr(II)/Ni(II)-mediated reaction of the aldehyde containing the citric acid moiety and the long-chain triflate, and the relative configuration of this natural product was determined.

Original languageEnglish
Pages (from-to)857-859
Number of pages3
JournalOrganic letters
Issue number6
Publication statusPublished - 2003 Mar 20
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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