Total synthesis of tetrahydropyran-containing natural products exploiting intramolecular oxa-conjugate cyclization

Haruhiko Fuwa

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    A growing number of tetrahydropyran-containing biologically active substances are being discovered from nature. Intramolecular oxa-conjugate cyclization (IOCC) is known as one of the most powerful methodologies for the stereoselective synthesis of substituted tetrahydropyran derivatives, although there is clearly room for methodological improvement. In this review, we describe our successful total synthesis of tetrahydropyran-containing natural products by exploiting IOCC and the discoveries that we have made during the course of the synthetic campaigns.

    Original languageEnglish
    Pages (from-to)1255-1298
    Number of pages44
    JournalHeterocycles
    Volume85
    Issue number6
    DOIs
    Publication statusPublished - 2012

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry

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