Total synthesis of (-)-strychnine

Yosuke Kaburagi; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1021/ja046407b

Total synthesis of (-)-strychnine

Yosuke Kaburagi, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

Total synthesis of (-)-strychnine is described. Notable features of our synthesis include (1) palladium-catalyzed coupling of the indole and vinyl epoxide moieties, (2) synthesis of the nine-membered cyclic amine derivative from the diol precursor in a one-pot procedure, and (3) transannular cyclization of the nine-membered cyclic amine.

Original language	English
Pages (from-to)	10246-10247
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	126
Issue number	33
DOIs	https://doi.org/10.1021/ja046407b
Publication status	Published - 2004 Aug 25
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja046407b

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abstract = "Total synthesis of (-)-strychnine is described. Notable features of our synthesis include (1) palladium-catalyzed coupling of the indole and vinyl epoxide moieties, (2) synthesis of the nine-membered cyclic amine derivative from the diol precursor in a one-pot procedure, and (3) transannular cyclization of the nine-membered cyclic amine.",

author = "Yosuke Kaburagi and Hidetoshi Tokuyama and Tohru Fukuyama",

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N2 - Total synthesis of (-)-strychnine is described. Notable features of our synthesis include (1) palladium-catalyzed coupling of the indole and vinyl epoxide moieties, (2) synthesis of the nine-membered cyclic amine derivative from the diol precursor in a one-pot procedure, and (3) transannular cyclization of the nine-membered cyclic amine.

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