Total synthesis of (-)-strychnine

Yosuke Kaburagi, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)

Abstract

Total synthesis of (-)-strychnine is described. Notable features of our synthesis include (1) palladium-catalyzed coupling of the indole and vinyl epoxide moieties, (2) synthesis of the nine-membered cyclic amine derivative from the diol precursor in a one-pot procedure, and (3) transannular cyclization of the nine-membered cyclic amine.

Original languageEnglish
Pages (from-to)10246-10247
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number33
DOIs
Publication statusPublished - 2004 Aug 25
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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