Abstract
A concise stereocontrolled total synthesis of (-)-rhazinilam was achieved by the regioselective 1,3-dipolar cycloaddition of a fully elaborated optically active münchnone intermediate prepared from d-aspartic acid dimethyl ester. The regiochemistry of the 1,3-dipolar cycloaddition of münchnone intermediate to various arylacetylenes was also investigated.
Original language | English |
---|---|
Pages (from-to) | 3619-3624 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 71 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2015 Jun 3 |
Keywords
- 1,3-Dipolar cycloaddition
- Alkaloids
- Münchnone
- Total synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry