Total synthesis of polygalolide A

Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

The total synthesis of polygalolide A was accomplished through intramolecular C-glycosylation of glucal modified with siloxyfuran. The siloxyfuran group and siloxy substituent at the C-3 position played crucial roles in allowing direct access to the highly substituted oxabicyclo[3.2.1] core skeleton with correct quaternary stereogenic centers.

Original languageEnglish
Pages (from-to)6532-6535
Number of pages4
JournalOrganic letters
Volume13
Issue number24
DOIs
Publication statusPublished - 2011 Dec 16
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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