Total synthesis of (-)-polycavernoside A: Suzuki-Miyaura coupling approach

Yusuke Kasai, Takanori Ito, Makoto Sasaki

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization.

    Original languageEnglish
    Pages (from-to)3186-3189
    Number of pages4
    JournalOrganic letters
    Volume14
    Issue number12
    DOIs
    Publication statusPublished - 2012 Jun 15

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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