Total synthesis of peumusolide A, NES non-antagonistic inhibitor for nuclear export of MEK

Satoru Tamura, Shunsuke Doke, Nobutoshi Murakami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The first total synthesis of peumusolide A (1) has been achieved by combination of regio- and stereo-selective aluminum-mediated hydroiodination to 2-yn-1-ol and enantioselective reduction of 4-en-1-yn-3-one with the chiral oxazaborolidine as the key reactions. This total synthesis has unequivocally established our proposed absolute structure of 1.

Original languageEnglish
Pages (from-to)8476-8480
Number of pages5
JournalTetrahedron
Volume66
Issue number43
DOIs
Publication statusPublished - 2010 Oct 23

Keywords

  • Asymmetric reduction
  • Hydroiodination
  • MEK-export inhibitor
  • Peumusolide A
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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