Abstract
A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.
Original language | English |
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Pages (from-to) | 2641-2643 |
Number of pages | 3 |
Journal | Chemical Communications |
Volume | 46 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2010 Apr 8 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry