Total synthesis of PDE-II by copper-mediated double amination

Kentaro Okano; Nakako Mitsuhashi; Hidetoshi Tokuyama

doi:10.1039/b926965g

Total synthesis of PDE-II by copper-mediated double amination

Kentaro Okano, Nakako Mitsuhashi, Hidetoshi Tokuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs₂CO₃ is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.

Original language	English
Pages (from-to)	2641-2643
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	15
DOIs	https://doi.org/10.1039/b926965g
Publication status	Published - 2010 Apr 8

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/b926965g

Cite this

@article{61af074eeb7b422d92dc653b492f4cd4,

title = "Total synthesis of PDE-II by copper-mediated double amination",

abstract = "A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.",

author = "Kentaro Okano and Nakako Mitsuhashi and Hidetoshi Tokuyama",

year = "2010",

month = apr,

day = "8",

doi = "10.1039/b926965g",

language = "English",

volume = "46",

pages = "2641--2643",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "15",

}

TY - JOUR

T1 - Total synthesis of PDE-II by copper-mediated double amination

AU - Okano, Kentaro

AU - Mitsuhashi, Nakako

AU - Tokuyama, Hidetoshi

PY - 2010/4/8

Y1 - 2010/4/8

N2 - A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.

AB - A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.

UR - http://www.scopus.com/inward/record.url?scp=77950361971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950361971&partnerID=8YFLogxK

U2 - 10.1039/b926965g

DO - 10.1039/b926965g

M3 - Article

C2 - 20461874

AN - SCOPUS:77950361971

VL - 46

SP - 2641

EP - 2643

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 15

ER -

Total synthesis of PDE-II by copper-mediated double amination

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this