Total synthesis of PDE-II by copper-mediated double amination

Kentaro Okano; Nakako Mitsuhashi; Hidetoshi Tokuyama

doi:10.1039/b926965g

Total synthesis of PDE-II by copper-mediated double amination

Kentaro Okano, Nakako Mitsuhashi, Hidetoshi Tokuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs₂CO₃ is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.

Original language	English
Pages (from-to)	2641-2643
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	15
DOIs	https://doi.org/10.1039/b926965g
Publication status	Published - 2010 Apr 8

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.",

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Total synthesis of PDE-II by copper-mediated double amination

Abstract

ASJC Scopus subject areas

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