Total synthesis of PDE-II by copper-mediated double amination

Kentaro Okano, Nakako Mitsuhashi, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


A concise total synthesis of PDE-II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and removal of an Ns group followed by rearomatization.

Original languageEnglish
Pages (from-to)2641-2643
Number of pages3
JournalChemical Communications
Issue number15
Publication statusPublished - 2010 Apr 8

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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