Abstract
A concise total synthesis of PDE-I and -II featuring copper-mediated double aryl amination with the combination of CuI, CsOAc, and Cs2CO 3 is described. The highly substituted pyrroloindole skeleton was constructed by a one-pot five-step sequence including double aryl amination, β-elimination, deprotection of a Cbz group, and unexpected formation of an indole via removal of an Ns group followed by rearomatization. The undesired elimination of the protecting group (Ns group) was hampered by using the Boc group as a protecting group in the second-generation synthesis, which excluded the reduction of the indole required in the first-generation synthesis.
Original language | English |
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Pages (from-to) | 10946-10954 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 69 |
Issue number | 51 |
DOIs | |
Publication status | Published - 2013 Dec 23 |
Keywords
- Amination
- Cascade reaction
- Copper
- One-pot reaction
- PDE
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry