Total synthesis of macrosphelide A by way of palladium-catalyzed carbonylative esterification

Shin Ichi Kusaka, Suguru Dohi, Takayuki Doi, Takashi Takahashi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We achieved the total synthesis of macrosphelide A, as part of a combinatorial library of its analogues. The key intermediate, the seco-acid derivative, was prepared from the corresponding vinyl iodide using sequential carbonylative esterification.

Original languageEnglish
Pages (from-to)8857-8859
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number49
DOIs
Publication statusPublished - 2003 Dec 1
Externally publishedYes

Keywords

  • Carbonylation
  • Macrolactone
  • Natural product synthesis
  • Palladium catalyst

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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