Total synthesis of (+)-haplophytine

Hirofumi Ueda; Hitoshi Satoh; Kóji Matsumoto; Kenji Sugimoto; Tohru Fukuyama; Hidetoshi Tokuyama

doi:10.1002/anie.200902192

Total synthesis of (+)-haplophytine

Hirofumi Ueda, Hitoshi Satoh, Kóji Matsumoto, Kenji Sugimoto, Tohru Fukuyama, Hidetoshi Tokuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

88 Citations (Scopus)

Abstract

Advancing alkaloid synthesis: (+)-Haplophytine (see structure) was the target of a total synthesis featuring a highly stereoselective intramolecular Mannich reaction, Friedel-Crafts alkylation, oxidative rearrangement, and Fischer indole synthesis.

Original language	English
Pages (from-to)	7600-7603
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	41
DOIs	https://doi.org/10.1002/anie.200902192
Publication status	Published - 2009 Sep 28

Keywords

Alkaloids
Mannich reaction
Natural products
Rearrangement
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200902192

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keywords = "Alkaloids, Mannich reaction, Natural products, Rearrangement, Total synthesis",

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AU - Ueda, Hirofumi

AU - Satoh, Hitoshi

AU - Matsumoto, Kóji

AU - Sugimoto, Kenji

AU - Fukuyama, Tohru

AU - Tokuyama, Hidetoshi

PY - 2009/9/28

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KW - Mannich reaction

KW - Natural products

KW - Rearrangement

KW - Total synthesis

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Total synthesis of (+)-haplophytine

Abstract

Keywords

ASJC Scopus subject areas

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