Total synthesis of (+)-haplophytine

Hirofumi Ueda, Hitoshi Satoh, Kóji Matsumoto, Kenji Sugimoto, Tohru Fukuyama, Hidetoshi Tokuyama

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)


Advancing alkaloid synthesis: (+)-Haplophytine (see structure) was the target of a total synthesis featuring a highly stereoselective intramolecular Mannich reaction, Friedel-Crafts alkylation, oxidative rearrangement, and Fischer indole synthesis.

Original languageEnglish
Pages (from-to)7600-7603
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number41
Publication statusPublished - 2009 Sep 28


  • Alkaloids
  • Mannich reaction
  • Natural products
  • Rearrangement
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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