Total Synthesis of Gymnocin-A

Chihiro Tsukano; Makoto Sasaki

doi:10.1021/ja038547b

Total Synthesis of Gymnocin-A

Chihiro Tsukano, Makoto Sasaki

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.

Original language	English
Pages (from-to)	14294-14295
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	47
DOIs	https://doi.org/10.1021/ja038547b
Publication status	Published - 2003 Nov 26

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1021/ja038547b

Fingerprint Dive into the research topics of 'Total Synthesis of Gymnocin-A'. Together they form a unique fingerprint.

Cite this

@article{c38af4e2322f4f80aed1439b7056759d,

title = "Total Synthesis of Gymnocin-A",

abstract = "A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.",

author = "Chihiro Tsukano and Makoto Sasaki",

year = "2003",

month = nov,

day = "26",

doi = "10.1021/ja038547b",

language = "English",

volume = "125",

pages = "14294--14295",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "47",

}

TY - JOUR

T1 - Total Synthesis of Gymnocin-A

AU - Tsukano, Chihiro

AU - Sasaki, Makoto

PY - 2003/11/26

Y1 - 2003/11/26

N2 - A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.

AB - A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.

UR - http://www.scopus.com/inward/record.url?scp=0344875200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344875200&partnerID=8YFLogxK

U2 - 10.1021/ja038547b

DO - 10.1021/ja038547b

M3 - Article

C2 - 14624575

AN - SCOPUS:0344875200

VL - 125

SP - 14294

EP - 14295

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

SN - 0002-7863

IS - 47

ER -

Total Synthesis of Gymnocin-A

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this