Total Synthesis of Gymnocin-A

Chihiro Tsukano, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.

Original languageEnglish
Pages (from-to)14294-14295
Number of pages2
JournalJournal of the American Chemical Society
Issue number47
Publication statusPublished - 2003 Nov 26

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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