Abstract
A highly convergent total synthesis of gymnocin-A, a cyctotoxic polyether marine natural product, has been achieved. The synthesis features Suzuki?Miyaura coupling of the ABCD and FGHIJKLMN rings, stereoselective introduction of the C17 hydroxyl group, ring-closure of the F ring, and a late-stage incorporation of a 2-methyl-2-butenal side chain.
| Original language | English |
|---|---|
| Pages (from-to) | 14294-14295 |
| Number of pages | 2 |
| Journal | Journal of the American Chemical Society |
| Volume | 125 |
| Issue number | 47 |
| DOIs | |
| Publication status | Published - 2003 Nov 26 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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Cite this
Tsukano, C., & Sasaki, M. (2003). Total Synthesis of Gymnocin-A. Journal of the American Chemical Society, 125(47), 14294-14295. https://doi.org/10.1021/ja038547b