Total synthesis of gambierol

Haruhiko Fuwa, Makoto Sasaki, Masayuki Satake, Kazuo Tachibana

Research output: Contribution to journalArticlepeer-review

77 Citations (Scopus)

Abstract

(Formula Represented) The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh3)4/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. † The University of Tokyo and CREST, JST. ‡ Tohoku University.

Original languageEnglish
Pages (from-to)2981-2984
Number of pages4
JournalOrganic letters
Volume4
Issue number17
DOIs
Publication statusPublished - 2002 Aug 22

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Total synthesis of gambierol'. Together they form a unique fingerprint.

Cite this