(Formula Represented) The first total synthesis of gambierol, a marine polycyclic ether toxin, has been achieved. The synthesis features the Pd(PPh3)4/CuCl/LiCl-promoted Stille coupling for the stereoselective construction of the sensitive triene side chain that includes a conjugated (Z,Z)-diene moiety. † The University of Tokyo and CREST, JST. ‡ Tohoku University.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry