Total synthesis of cortistatins A and J

Shuji Yamashita, Kentaro Iso, Kazuki Kitajima, Masafumi Himuro, Masahiro Hirama

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)

Abstract

This paper describes the details of our synthetic studies on the marine steroidal alkaloids cortistatins A and J. The key features of our strategy include (i) an efficient Knoevenagel/electrocyclic strategy to couple the diketone and the CD-ring fragment, (ii) a chemoselective radical cyclization to construct the oxabicyclo[3.2.1]octene B-ring system, (iii) a highly stereocontrolled installation of the isoquinoline unit, and (iv) a late-stage functionalization of the A-ring.

Original languageEnglish
Pages (from-to)2408-2425
Number of pages18
JournalJournal of Organic Chemistry
Volume76
Issue number8
DOIs
Publication statusPublished - 2011 Apr 15

ASJC Scopus subject areas

  • Organic Chemistry

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