Total Synthesis of Calicheamicin–Dynemicin Hybrid Molecules

K. C. Nicolaou, Erwin P. Schreiner, Yoshiharu Iwabuchi, Toshio Suzuki

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Synthetic enediyne cytostatics/antibiotics are the goal of the preparative work described here. Of the four isomeric calicheamicin‐dynemicin hybrid compounds obtained, only those with the same configuration as calicheamin at all stereocenters are cytostatically active. One of the active isomers is 1. (Figure Presented.)

Original languageEnglish
Pages (from-to)340-342
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume31
Issue number3
DOIs
Publication statusPublished - 1992 Mar
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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