Total synthesis of aspergillides A, B, and C

Tomohiro Nagasawa, Shigefumi Kuwahara

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)


    Aspergillides A, B, and C are cytotoxic macrolides produced by the marine-derived fungus Aspergillus ostianus strain TUF 01F313. The unique molecular architectures of the aspergillides featuring 14-membered marocyclic structures embedded with a tetrahydro-or dihydropyran unit have attracted significant attention from the synthetic chemistry community, and thereby various synthetic approaches to these structurally as well as pharmacologically intriguing molecules have been reported by as many as 12 research groups in the past 3 years. This review describes all of the syntheses disclosed to date, focusing mainly on the methodologies employed for the diastereoselective installation of the pyran ring systems..

    Original languageEnglish
    Pages (from-to)587-613
    Number of pages27
    Issue number3
    Publication statusPublished - 2012 Feb 27

    ASJC Scopus subject areas

    • Analytical Chemistry
    • Pharmacology
    • Organic Chemistry


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