Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Asif Ali, Markus R. Wenk, Martin J. Lear

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its d-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2).

Original languageEnglish
Pages (from-to)5664-5666
Number of pages3
JournalTetrahedron Letters
Volume50
Issue number40
DOIs
Publication statusPublished - 2009 Oct 7

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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