Total synthesis and structure revision of the (-)-maduropeptin chromophore

Kazuo Komano, Satoshi Shimamura, Yutaro Norizuki, Donglin Zhao, Chizuko Kabuto, Itaru Sato, Masahiro Hirama

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

(Chemical Equation Presented) The proposed structure of the maduropeptin chromophore, the biologically active component of the highly potent chromoprotein antitumor antibiotics, was stereoselectively synthesized but did not satisfy the spectra of the natural product. We demonstrated that the correct structure is diastereomeric, which possesses an antipodal sugar moiety.

Original languageEnglish
Pages (from-to)12072-12073
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number34
DOIs
Publication statusPublished - 2009 Sep 2

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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  • Cite this

    Komano, K., Shimamura, S., Norizuki, Y., Zhao, D., Kabuto, C., Sato, I., & Hirama, M. (2009). Total synthesis and structure revision of the (-)-maduropeptin chromophore. Journal of the American Chemical Society, 131(34), 12072-12073. https://doi.org/10.1021/ja905397p