Total synthesis and complete structural assignment of gambieric acid A, a large polycyclic ether marine natural product

Makoto Sasaki, Haruhiko Fuwa

    Research output: Contribution to journalReview articlepeer-review

    8 Citations (Scopus)

    Abstract

    More than thirty years after the discovery of polycyclic ether marine natural products, they continue to receive intense attention from the chemical, biological, and pharmacological communities because of their potent biological activities and highly complex molecular architectures. Gambieric acids are intriguing polycyclic ethers that exhibit potent antifungal activity with minimal toxicity against mammals. Despite the recent advances in the synthesis of this class of natural products, gambieric acids remain unconquered due to their daunting structural complexity, which poses a formidable synthetic challenge to organic chemists. This paper reviews our long-term studies on the total synthesis, complete configurational reassignment, and structure-activity relationships of gambieric acid A over the last decade.

    Original languageEnglish
    Pages (from-to)678-703
    Number of pages26
    JournalChemical record (New York, N.Y.)
    Volume14
    Issue number4
    DOIs
    Publication statusPublished - 2014 Aug 1

    Keywords

    • gambieric acids
    • marine dinoflagellates
    • natural products
    • polycyclic ethers
    • total synthesis

    ASJC Scopus subject areas

    • Chemistry(all)
    • Biochemistry
    • Chemical Engineering(all)
    • Materials Chemistry

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