Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

K. C. Nicolaou, Xuefeng Jiang, Peter J. Lindsay-Scott, Andrei Corbu, Sawako Yamashiro, Andrea Bacconi, Velia M. Fowler

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.

    Original languageEnglish
    Pages (from-to)1139-1144
    Number of pages6
    JournalAngewandte Chemie - International Edition
    Volume50
    Issue number5
    DOIs
    Publication statusPublished - 2011 Feb 1

    Keywords

    • macrolactonization
    • natural products
    • polyketides
    • total synthesis

    ASJC Scopus subject areas

    • Catalysis
    • Chemistry(all)

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