Abstract
Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.
Original language | English |
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Pages (from-to) | 1139-1144 |
Number of pages | 6 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2011 Feb 1 |
Keywords
- macrolactonization
- natural products
- polyketides
- total synthesis
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)