Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

K. C. Nicolaou; Xuefeng Jiang; Peter J. Lindsay-Scott; Andrei Corbu; Sawako Yamashiro; Andrea Bacconi; Velia M. Fowler

doi:10.1002/anie.201006780

Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

K. C. Nicolaou, Xuefeng Jiang, Peter J. Lindsay-Scott, Andrei Corbu, Sawako Yamashiro, Andrea Bacconi, Velia M. Fowler

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Abstract

Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.

Original language	English
Pages (from-to)	1139-1144
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	5
DOIs	https://doi.org/10.1002/anie.201006780
Publication status	Published - 2011 Feb 1
Externally published	Yes

Keywords

macrolactonization
natural products
polyketides
total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.201006780

Cite this

Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin. / Nicolaou, K. C.; Jiang, Xuefeng; Lindsay-Scott, Peter J.; Corbu, Andrei; Yamashiro, Sawako; Bacconi, Andrea; Fowler, Velia M.

In: Angewandte Chemie - International Edition, Vol. 50, No. 5, 01.02.2011, p. 1139-1144.

Research output: Contribution to journal › Article › peer-review

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AU - Fowler, Velia M.

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Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

Abstract

Keywords

ASJC Scopus subject areas

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