Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin

K. C. Nicolaou, Xuefeng Jiang, Peter J. Lindsay-Scott, Andrei Corbu, Sawako Yamashiro, Andrea Bacconi, Velia M. Fowler

Research output: Contribution to journalArticlepeer-review

51 Citations (Scopus)

Abstract

Convergence and a biological dichotomy! Monorhizopodin (see structure) and its C16 epimer have been synthesized through a highly convergent strategy. Unlike the antitumor agent rhizopodin which is their naturally occurring dimer, monorhizopodin and its epimer exhibit potent inhibition of actin polymerization but no significant cytotoxicity.

Original languageEnglish
Pages (from-to)1139-1144
Number of pages6
JournalAngewandte Chemie - International Edition
Volume50
Issue number5
DOIs
Publication statusPublished - 2011 Feb 1
Externally publishedYes

Keywords

  • macrolactonization
  • natural products
  • polyketides
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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